Zhu Laboratory

Selected Publications

* denotes equal contribution

Zhu Q*, Jiang J*, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Dastidar GS, Rodriguez M, King P, Zhang YJ, Spada A, Xu H, Petrucelli L, Ravits J, Da Cruz S, Lagier-Tourenne C, Cleveland DW. 2020. Reduced C9ORF72 function exacerbates gain-of-toxicity from ALS/FTD-causing repeat expansions in C9orf72. Nat Neurosci 23(5):615–624.

Xiao G, Du J, Wu h, Ge X, Xu X, Yang A, Zhu Y, Hu X, Zheng K, Zhu Q, Qiu M. 2020. Differential inhibition of Sox10 functions by Notch-Hes pathway. Cell Mol Neurobiol 40(4):653–662.

Jiang J*, Zhu Q*, Gendron TF*, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, Katz M, Baughn M, Platoshyn O, Marsala M, Watt A, Heyser CJ, Ard MC, De Muynck L, Daughrity LM, Swing DA, Tessarollo L, Jung CJ, Delpoux A, Utzschneider DT, Hedrick SM, de Jong PJ, Edbauer D, Van Damme P, Petrucelli L, Shaw CE, Bennett CF, Da Cruz S, Ravits J, Rigo F, Cleveland DW, Lagier-Tourenne C. 2016. Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs. Neuron 90(3):535–550.

Zhu Q, Tan Z, Zhao SF, Huang H, Zhao XF, Hu XM, Zhang YP, Shields CB, Uetani N and Qiu M. 2015. Developmental expression and function of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination. Neuroscience 308:106–114.

Zhu Q*, Zhao X*, Zheng K*, Li H, Huang H, Zhang Z, Mastracci T, Wegner M, Chen Y, Sussel L, Qiu M. 2014. Genetic evidence that Nkx2.2 and Pdgfra are major determinants of the timing of oligodendrocyte differentiation in the developing CNS. Development 141(3):548–555.

Zhao X*, Chen Y*, Zhu Q, Huang H, Teng P, Zheng K, Hu X, Xie B, Zhang Z, Sander M, Qiu M. 2014. Control of astrocyte progenitor specification, migration and maturation by Nkx6.1 homeodomain transcription factor. PLoS One 9(10):e109171.

Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling SC, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu XD, Bennett CF, Cleveland DW, Ravits J. 2013. Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A 110(47):E4530–4539.

Zhu Q, Whittemore SR, DeVries WH, Zhao XF, Kuypers NJ, Qiu M. 2011. Dorsally derived oligodendrocytes in the spinal cord contribute to axonal myelination during development and remyelination following focal demyelination. Glia 59(11):1612–1621.

Cai J, Zhu Q, Zheng K, Li H, Cao QL and Qiu M. 2010. Co-localization of Nkx6.2 and Nkx2.2 homeodomain proteins in differentiated myelinating oligodendrocytes. Glia 58(4):458–468.

Zheng K, Li H, Zhu Y, Zhu Q and Qiu M. 2010. MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord. J Neurosci 30(24):8245–8250.

Park J, Liu B, Chen T, Li H, Hu, X, Gao J, Zhu Y, Zhu Q, Qiang B, Yuan J, Peng X and Qiu M. 2008. Disruption of Necl-1 cell adhesion molecule leads to delayed axonal myelination in the developing nervous system. J Neurosci 28 (48):12815–12819.

Zhao S, Hu X, Park J, Zhu Y, Zhu Q, Luo C, Han R, Cooper N. and Qiu M. 2007. Selective expression of LDLR and VLDLR in myelinating oligodendrocytes. Develop Dynam 236 (9):2708–2712.

Zhu Q, Chang H, Chen Y, Fang F, Xue C, Zhang F, Qiu M, Wang H, Wang B, Chen Z. 2005. Protection of inactivated influenza virus vaccine against lethal influenza virus infection in diabetic mice. Biochem Biophys Res Commun 329(1):87c94.

Tang L, Zhu Q, Qin E, Yu M, Ding Z, Shi H, Cheng X, Wang C, Chang G, Zhu Q, Fang F, Chang H, Li S, Zhang X, Chen X, Yu J, Wang J, Chen Z. 2004. Inactivated SARS-CoV vaccine prepared from whole virus induces a high level of neutralizing antibodies in BALB/c mice. DNA Cell Biol 23(6):391–394.